I normally do it if it is clear that a small clue will provide a lot of information. For example, if there is a clue that can easily be split into a small number of defined boards (2-4) AND each of those boards will have enough info to make 1 or 2 semi-major inferences, them I will split.
I also will split on questions that generate 1-3 boards and if questions give me a new idea of what the game is like.
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I also will split on questions that generate 1-3 boards and if questions give me a new idea of what the game is like.