Self-paced
P1
Until recently, biologists were unable to explain the fact that pathogens—disease-causing parasites—have evolved to incapacitate, and often overwhelm, their hosts. ████ ████████ ██ ██ ████ ████ ███ ██████████ ████ ██ █████████████ █████████████████ ██ ████████ ████ ███ ████████ ██████████ ███████ █ ██████ ████████████ ████ ████ ██ █████ ██ ███ ████ ████ █████████ ████ ██ ███ ████ █████ █████ ████ ███ ████ ██████ ███ █████████ █████████ ████ ██████ ███████ █████ █████ ███████ ███
Puzzling Phenomenon ·
Pathogens incapacitate and kill hosts
This is puzzling because the prevailing view is that parasites need their hosts for long-term survival.
Hypothesis ·
Trade-off
Pathogen can cause hosts to be very sick or even die if it can spread to a new host. So it's trading away staying in the current host for jumping to a new host.
P2
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Implication ·
Virulence is function of mode transmission
Virulence means the ability to defeat the host's defenses and incapacitate the host.
Example ·
Close contact transmission requires low virulence
Rhinoviruses (common cold) requires physical contact for transmission. Hence, it cannot be too virulent. If it were, then the host would be confined in solitude (or die) and the virus would not be able to jump to a new host. It needs to be only mildly virulent so that the host can help it jump to new hosts.
P3
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Example ·
Vector transmission requires high virulence
If a pathogen can be transmitted via a vector (e.g., mosquito), then virulence can and perhaps must be high. It needs to reproduce so extensively (and hence severely harm the host) such that the vector (e.g., mosquito) can acquire enough of the pathogen to transmit it to a new host.
P4
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Anomalies ·
"Sit and wait" pathogens
In general, the literature supports the hypothesis. But "sit and wait" pathogens like diphtheria and tuberculosis are directly transmitted yet lethal. They can do this because they can survive outside their hosts for up to months. This makes them the most dangerous kind of pathogen.
Passage Style
Phenomenon-hypothesis (RC)
Single position
20.
According to the passage, the ██████████ ████ ██ ███ █████████████ ████████████ ██ █████ ██ ████████
a
the host is ██████████ ██████ ██████ ██ ███████ ███ ████████ ████ ████████
b
a thriving parasite ████ ██████████ ████████████ ███ ████
c
a parasite must ██████████ ██ ███████████ ██ █ ███ ████ ██ █████ ██ ███████
Not supported as something the prevailing view holds. A benign coexistence doesn’t relate to transmission. Discussion of transmission in order for survival comes in later in P1, in connection with the hypothesis regarding pathogens that don’t have a benign coexistence with their hosts.
d
the parasite eventually ███████ ████ ██ ████ ██ ███ ████
e
ultimately the host ███████ ████ ██ ███ ████████ ███████
Not supported as something the prevailing view holds. A benign coexistence is one where each side benefits. We have no reason to think the benign coexistence described creates a requirement (”only if”) for the host’s thriving.