Rats fed high doses of the artificial sweetener saccharin develop silicate crystals that are toxic to cells lining the bladder. ████ ███ █████ ███████████ ████ ███ █████████ ███ ████ ███████ ██████ █████ ████ ███ ████ █████ ██ █████████ ██ ███ ███ ███████ ███████
Why don’t mice develop bladder cancer when fed high doses of saccharin, even though rats who are fed high doses of saccharin do develop such cancer?
The correct answer should tell me something different about mice compared to rats that would inhibit the development of bladder cancer. It probably has something to do with silicate crystals, which the stimulus says are toxic to cells in rat bladders.
Which one of the following, ██ █████ ████ ███ ████ ██ ███████ ███ ████████ ███████████ ██ ███ ███████████ ██████
Urine proteins that █████ ████ █████████ ██ ████ ████████ ████████ ███ █████ ██ ████ ███ ███ ██ █████
Saccharin in rats leads to toxic silicate crystals in their bladders. This answer suggests saccharin in mice won’t develop silicate crystals in their bladders, which could explain why mice don’t get bladder cancer from saccharin.
Cells in the ███████ ██████████ ████ ███████ ██ ████ ████ ████ ██ ██ █████
Is faster regeneration of cells something that would prevent bladder cancer? We don’t know.
High doses of █████████ ███ ████ ████ ██████ ██ ███████ ████████ ████████ ████ █████ █████ ████
This doesn’t help differentiate mice and rats. So, it can’t help explain the different reactions in mice and rats to saccharin.
The silicate crystals ███ █████ ████ ██ ███ █████ ██████ ███ ███████ ███ ███ ██ █████ ███████ ██████
This doesn’t help differentiate mice and rats. So, it can’t help explain the different reactions in mice and rats to saccharin.
High doses of █████ ██████████ ██████████ ████ ████ █████ ██ ███████ ████████ ████████ ██ ████ ███ ███ ██ █████
This makes the lack of bladder cancer in mice who are given saccharin more difficult to explain. Saccharin is an artificial sweetener, so we might think mice would react similarly to saccharin as to the other sweeteners mentioned in this answer.
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