Is it just me or is the question stem weirdly worded? I swear I speak English... took me more than a minute

Which video did you watch?

Same!

Answer E is paraphrasing the conclusion, which is the second sentence. The author starts with context in the first sentence, introduces "but" to shift from that context to his own argument. It's helpful to test individual sentences/ suspected conclusion by asking "why?" --

Shift from context into conclusion: "But we need to determine whether the changes are warranted, taking into account their price." --> OK, why?

Support sentences 1-3... explain why. They're costly which has further implications like restrictions in other areas.

Therefore...,

Last sentence (hypothesized conclusion for you): [But] such massive interventions would be costly and would change the character or science."

Last sentence serves as a sub-conclusion for the major premises that are answering the "why", also making it a sentence explaining "why"....

Why what? Why we need to "determine whether the changes [to the way science is conducted and regulated] are warranted, taking into account price.

I'm down! Lets get an NYC group chat going.