Multiple sclerosis is an autoimmune disease: white blood cells attack the myelin sheath that protects nerve fibers in the spinal cord and brain. Medical science now has a drug that can be used to successfully treat multiple sclerosis, but the path that led medical researchers to this drug was hardly straightforward. Initially, some scientists believed attacks characteristic of multiple sclerosis might be triggered by chronic viral infections. So in 1984 they began testing gamma interferon, one of the body’s own antiviral weapons. To their horror, all the multiple sclerosis patients tested became dramatically worse. The false step proved to be instructive however.
Summary
Scientists thought multiple sclerosis (MS) was caused by viral infections. To test this hypothesis, they used gamma interferon—a tool the body uses to combat viral infections—to treat MS. This experiment, however, resulted in the MS patients’ conditions worsening.
Notable Valid Inferences
Gamma interferon makes MS worse.
A
Gamma interferon stops white blood cells from producing myelin-destroying compounds.
This is not compatible with the experiment’s results. If gamma interferon does what (A) claims, it would interfere with the mechanism that makes MS so destructive. This would likely improve MS patients’ conditions—this contradicts the experiment, which shows the opposite effect.
B
Administering gamma interferon to those without multiple sclerosis causes an increase in the number of white blood cells.
This could be true and may explain why gamma interferon makes MS patients’ conditions worse. By causing an increase in white blood cells, gamma interferon could increase the number of cells attacking the myelin sheath in MS patients.
C
Medical researchers have discovered that the gamma interferon level in the cerebrospinal fluid skyrockets just before and during multiple sclerosis attacks.
This could be true and may explain why gamma interferon makes MS patients’ conditions worse. It suggests an association between increased gamma interferon levels and MS attacks.
D
It has now been established that most multiple sclerosis sufferers do not have chronic viral infections.
This could be true. It suggests that scientists’ initial belief that MS is triggered by viral infections is incorrect. This could explain why gamma interferon, one of the body’s antiviral tools, is ineffective against it.
E
The drug now used to treat multiple sclerosis is known to inhibit the activity of gamma interferon.
This could be true and may explain why gamma interferon makes MS patients’ conditions worse. It suggests that inhibiting gamma interferon levels improves patients’ conditions—this is consistent with the finding that increasing gamma interferon levels worsens patients’ conditions.
A
It limits the application of the argument to a part of the problem.
B
It suggests that the primary cause of homelessness is lack of available housing.
C
It is offered as evidence crucial to the conclusion.
D
It expresses the conclusion to be argued for.
E
It suggests a possible solution to the problem of homelessness.
A
Few contemporary artists have been significantly exposed to the art of earlier cultures.
B
The arts held a much more important place in earlier cultures than they do in our culture.
C
Our own standard of beauty was strongly influenced by our exposure to works that were considered beautiful in earlier cultures.
D
Much of what passes for important artistic work today would not be considered beautiful even by contemporary standards.
E
In most cultures art is owned by a small social elite.
The researcher also assumes that the hospital records give a complete and accurate picture of the situation. If the hospitals’ data entry is flawed, then even the correlation may not be reliable.
A
The hospital records indicate that many babies that are born with normal birth weights are born to mothers who had inadequate prenatal care.
B
Mothers giving birth prematurely are routinely classified by hospitals as having received inadequate prenatal care when the record of that care is not available.
C
The hospital records indicate that low birth weight babies were routinely classified as having been born prematurely.
D
Some babies not born prematurely, whose mothers received adequate prenatal care, have low birth weights.
E
Women who receive adequate prenatal care are less likely to give birth prematurely than are women who do not receive adequate prenatal care.